"A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states" Somvanshi, V.S., Sloup, R.E., Crawford, J.M., Martin, A.R., Heidt, A.J., Kim, K.S., Clardy, J., Ciche, T.A. 2012. Science. 337(6090): 88-93. Pubmed Link
"A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants" Chen, Y., Cao, S., Chai, Y., Clardy, J., Kolter, R., Guo, J.H., Losick, R. Mol Microbiol 2012. [Epub ahead of print]. Pubmed Link
"Small molecule perimeter defense in entomopathogenic bacteria" Crawford, J.M., Portmann, C., Zhang, X., Roeffaers, M.B., Clardy, J. Proc Natl Acad Sci USA. 2012 [Epub ahead of print]. Pubmed Link
"Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin" Carr, G., Poulsen, M., Klassen, J.L., Hou, Y., Wyche, T.P., Bugni, T.S., Currie, C.R., Clardy, J. Org Lett. 2012. 14(11): 2822-5. Pubmed Link
"Liver-stage malaria parasites vulnerable to diverse chemical scaffolds" Derbyshire, E.R., Prud?ncio, M., Mota, M.M., Clardy, J. Proc Natl Acad Sci USA. 2012.109(22): 8511-6. Pubmed Link
"Microbial genome mining answers longstanding biosynthetic questions" Crawford, J.M., Clardy, J. Proc Natl Acad Sci USA. 2012. 109(20): 7589-90. Pubmed Link
"A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide" Kolodkin-Gal, I.; Cao, S.; Chai, L.; B?ttcher, T.; Kolter, R.; Clardy, J.; Losick, R. Cell. 2012. 149(3): 684-92. Pubmed Link
"Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp." Cao, S.; McMillin, D.W.; Tamayo, G.; Delmore, J.; Mitsiades, C.S.; Clardy, J. J Nat Prod. 2012 75(4): 793-7. Pubmed Link
"A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity" Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI. PLoS One. 2012. 7(2): e31307. Open Access
"The next opportunity in anti-malaria drug discovery: the liver stage" Derbyshire, E.R; Mota, M.M.; Clardy, J. PLoS Pathogen. 2011. 7(9), e1002178. Pubmed Link
"Dihydrophenylalanine: A prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis" Crawford, J.M.; Mahlstedt, S.A.; Malcolmson, S.J.; Clardy, J.; Walsh, C.T. Chem Biol. 2011. 18(9): 1102-1112. Pubmed Link
"Roseobacticides: Small molecule modulators of an algal-bacterial symbiosis" Seyedsayamdost, M.R.; Carr, G.; Kolter, R.; Clardy, J. J Am Chem Soc. 2011. 133(45): 18343?18349. Open Access
"NRPS substrate promiscuity diversifies the xenematides" Crawford, J.M.; Portmann, C.; Kontnik, R.; Walsh, C.T.; Clardy, J. Org Lett. 2011. 13(19): 5144-5147. Open Access
"Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines" Harris, E.S.; Cao, S.; Littlefield, B.A.; Craycroft, J.A.; Scholten, R.; Kaptchuk, T.; Fu, Y.; Wang, W.; Liu, Y.; Chen, H.; Zhao, Z.; Clardy, J.; Woolf, A.D.; Eisenberg, D.M. Sci Total Environ. 2011. 409, (20), 4297-305. Pubmed Link
"Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4" Seyedsayamdost, M.R.; Traxler, M.F.; Zheng, S.L.; Kolter, R.; Clardy, J. J Am Chem Soc. 2011. 133, (30), 11434-7. Pubmed Link
"New naphthoquinones and a new delta-lactone produced by endophytic fungi from Costa Rica" Cao, S.; Clardy, J. Tetrahedron Lett. 2011. 52, (17), 2206-2208. Pubmed Link
"Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264" Carr, G.; Seyedsayamdost, M.R.; Chandler, J.R.; Greenberg, E.P.; Clardy, J. Org Lett. 2011. 13, (12), 3048-51. Pubmed Link
"Bacterial symbionts and natural products" Crawford, J.M.; Clardy, J. Chem Commun. 2011. 47, (27), 7559-66. Pubmed Link
"The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis" Seyedsayamdost, M.R.; Case, R.J.; Kolter, R.; Clardy, J. Nat Chem. 2011. 3, (4), 331-5. Pubmed Link
"Aminoindoles: a Novel Scaffold with Potent Activity against Plasmodium falciparum" Barker, R.H. Jr.; Urgaonkar, S.; Mazitschek, R.; Celatka, C.; Skerlj, R.; Cortese, J.F.; Tyndall, E.; Liu, H.; Cromwell, M.; Sidhu, A.B.; Guerrero-Bravo, J.E.; Crespo-Llado, K.N.; Serrano, A.E.; Lin, J.W.; Janse, C.J.; Khan, S.M.; Duraisingh, M.; Coleman, B.I.; Angulo-Barturen, I.; Jimenez-Diaz, M.B.; Magan, N.; Gomez, V.; Ferrer, S.; Santos Martinez, M.; Wittlin, S.; Papastogiannidis, P.; O'Shea, T.; Klinger, J.D.; Bree, M.; Lee, E.; Levine, M.; Wiegand, R.C.; Munoz, B.; Wirth, D.F.; Clardy, J.; Bathurst, I.; Sybertz, E. Antimicrob Agents Chemother. 2011. Mar 21. Epub ahead of print. Pubmed Link
"Traditional Medicine Collection Tracking System (TM-CTS): A database for ethnobotanically driven drug-discovery programs" Harris, E.S.; Erickson, S.D.; Tolopko, A.N.; Cao, S.; Craycroft, J.A.; Scholten, R.; Fu, Y.; Wang, W.; Liu, Y.; Zhao, Z.; Clardy, J.; Shamu, C.E.; Eisenberg, D.M. J Ethnopharmacol. 2011. Mar 21. Epub ahead of print. Pubmed Link
"Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery" Poulsen, M.; Oh, D.C.; Clardy, J.; Currie, C.R. PLoS One. 2011. 6, (2), e16763. Pubmed Link
"The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes" Marks, K.M.; Park, E.S.; Arefolov, A.; Russo, K.; Ishihara, K.; Ring, J.E.; Clardy, J.; Clarke, A.S.; Pelish, H.E. J Nat Prod. 2011. Feb 24. Epub ahead of print. Pubmed Link
"Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp" Oh, D.C.; Poulsen, M.; Currie, C.R.; Clardy, J. Org Lett. 2011. 13, (4), 752-5. Pubmed Link
"Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration", Eisenberg, D.M.; Harris, E.S.; Littlefield, B.A.; Cao, S.; Craycroft, J.A.; Scholten, R.; Bayliss, P.; Fu, Y.; Wang, W.; Qiao, Y.; Zhao, Z.; Chen, H.; Liu, Y.; Kaptchuk, T.; Hahn, W.C.; Wang, X.; Roberts, T.; Shamu, C.E.; Clardy, J. Fitoterapia. 2011. 82, (1), 17-33. Pubmed Link
"Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone", Mao, Y.; Xu, X.; Xu, W.; Ishida, Y.; Leal, W.S.; Ames, J.B.; Clardy, J. Proc Natl Acad Sci USA. 2010. 107 (44), 19102-7. Pubmed Link
"Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans", Yamada, K.; Hirotsu, T.; Matsuki, M.; Butcher, R.A.; Tomioka, M.; Ishihara, T.; Clardy, J.; Kunitomo, H.; Iino, Y. Science. 2010. 329, (5999), 1647-50. Pubmed Link
"Biosynthesis: Not just passing through", Crawford, J.M.; Clardy, J. Nat Chem. 2010. 2, (10), 805-7. Pubmed Link
"Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain", Cao, S.; Blodgett, J.A.; Clardy, J. Org Lett. 2010. 12, (20), 4652-4. Pubmed Link
"Asterogynins: secondary metabolites from a Costa Rican endophytic fungus", Cao, S.; Ross, L.; Tamayo, G.; Clardy, J. Org Lett. 2010. 12, (20), 4661-3. Pubmed Link
"A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity", Urgaonkar, S.; Cortese, J.F.; Barker, R.H.; Cromwell, M.; Serrano, A.E.; Wirth, D.F.; Clardy, J.; Mazitschek, R. Org Lett. 2010. 12, (18), 3998-01. Pubmed Link
"Psychotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin", Schloss, P.D.; Allen, H.K.; Klimowicz, A.K.; Mlot, C.; Gross, J.A.; Savengsuksa, S.; McEllin, J.; Ruess, R.W.; Handelsman, J. DNA Cell Biol. 2010. 29, (9), 533-541. Pubmed Link
"Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria", Blodgett, J.A.; Oh, D.C.; Cao, S.; Currie, C.R.; Kolter, R.; Clardy, J. Proc Natl Acad Sci USA. 2010. 107, (26), 11692-7. Pubmed Link
"Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens", Kontnik, R.; Crawford, J.M.; Clardy, J. ACS Chem Biol. 2010. 5, (7), 659-665. Pubmed Link
"D-amino acids trigger biofilm disassembly", Kolodkin-Gal, I.; Romero, D.; Cao, S.; Clardy, J.; Kolter, R.; Losick, R. Science. 2010. 328, (5978), 627-629. Pubmed Link
"Siderophores from neighboring organisms promote the growth of uncultured bacteria", D'Onofrio, A.; Crawford, J.M.; Stewart, E.J.; Witt, K.; Gavrish, E.; Epstein, S.; Clardy, J.; Lewis, K. Chem Biol. 2010. 17, (3), 254-264. Pubmed Link
"Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum", Freinkman, E.; Oh, D.C.; Scott, J.J.; Currie, C.R.; Clardy, J. Tetrahedron Lett. 2009. 50, (49), 6834-6837. Pubmed Link
"A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal", Ndiaye, D.; Patel, V.; Demas, A.; LeRoux, M.; Ndir, O.; Mboup, S.; Clardy, J.; Lakshmanan, V.; Daily, J.P.; Wirth, D.F. Am J Trop Med Hyg. 2010. 82, (2), 228-230. Pubmed Link
"Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264", Seyedsayamdost, M.R.; Chandler, J.R.; Blodgett, J.A.; Lima, P.S.; Duerkop, B.A.; Oinuma, K.; Greenberg, E.P.; Clardy, J. Org Lett. 2010. 12, (4), 716-719. Pubmed Link
"Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases", Dawlaty, J.; Zhang, X.; Fischbach, M.A.; Clardy, J. J Nat Prod. 2010. 73, (3), 441-446. Pubmed Link
"Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression", Blasiak, L.C.; Clardy, J. J Am Chem Soc. 2010. 132, (3), 926-927. Pubmed Link
"Regulating alternative lifestyles in entomopathogenic bacteria", Crawford, J.M.; Kontnik, R.; Clardy, J. Curr Biol. 2010. 20, (1), 69-74. Pubmed Link
"Target identification using drug affinity responsive target stability (DARTS)", Lomenick, B.; Hao, R.; Jonai, N.; Chin, R.M.; Aghajan, M.; Warburton, S.; Wang, J.; Wu, R.P.; Gomez, F.; Loo, J.A.; Wohlschlegel, J.A.; Vondriska, T.M.; Pelletier, J.; Herschman, H.R.; Clardy, J.; Clarke, C.F.; Huang, J. Proc Natl Acad Sci USA. 2009, 106, (51), 21984-21989. Pubmed Link
"Antiplasmodial activity of piperazine sulfonamides", Martyn, D.C.; Cortese, J.F.; Tyndall, E.; Dick, J.; Mazitschek, R.; Munoz, B.; Clardy, J. Bioorg Med Chem Lett. 2010, 20, (1), 218-221. Pubmed Link
"Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines", Martyn, D.C.; Nijjar, A.; Celatka, C.A.; Mazitschek, R.; Cortese, J.F.; Tyndall, E.; Liu, H.; Fitzgerald, M.M.; O'Shea, T.J.; Danthi, S.; Clardy, J. Bioorg Med Chem Lett. 2010, 20, (1), 228-231. Pubmed Link
"Chemical modification of the insecticidal briantheins X and Y (parallel)", Cronan, J.M.; Lee, A.; Liang, J; Clardy, J.; Cardellina, J.H. J. Nat. Prod. 2010, 73, (3), 346-351. Pubmed Link
"The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics", Hollenhorst, M.A.; Clardy, J.; Walsh, C.T. Biochemistry. 2009, 48, (43), 10467-72. Pubmed Link
"Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans", Kim, K.; Sato, K.; Shibuya, M.; Zeiger, D.M.; Butcher, R.A.; Ragains, J.R.; Clardy, J.; Touhara, K.; Sengupta, P. Science. 2009, 326, (5955), 994-8. Pubmed Link
"D-amino acids govern stationary phase cell wall remodeling in bacteria", Lam, H.; Oh, D.C.; Cava, F.; Takacs, C.N.; Clardy, J.; de Pedro, M.A.; Waldor, M.K. Science. 2009, 325, (5947), 1552-5. Pubmed Link
"Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum", Martyn, D.C.; Beletsky, G.; Cortese, J.F.; Tyndall, E.; Liu, H.; Fitzgerald, M.M.; O'Shea, T.J.; Liang, B.; Clardy, J. Bioorg Med Chem Lett. 2009, 19, (19), 5657-60. Pubmed Link
"FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases", Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, S.N.; Zhou, W.; Liu, Y.; Neve, R.L.; Taylor, J.P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R.G. J Neurosci. 2009, 29, (25), 8236-47. Pubmed Link
"An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations", Butcher, R.A.; Ragains, J.R.; Clardy, J. Org Lett. 2009, 11, (14), 3100-3. Pubmed Link
"A stabilized demethoxyviridin derivative inhibits PI3 kinase", Yuan, H.; Pupo, M.T.; Blois, J.; Smith, A.; Weissleder, R.; Clardy, J.; Josephson, L. Bioorg Med Chem Lett. 2009, 19, (15), 4223-7. Pubmed Link
"The natural history of antibiotics", Clardy, J.; Fischbach, M.A.; Currie, C.R. Curr Biol. 2009, 19, (11), 437-41. Pubmed Link
"A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans", Macosko, E.Z.; Pokala, N.; Feinber, E.H.; Chalasani, S.H.; Butcher, R.A.; Clardy, J.; Bargmann, C.I. Nature. 2009, 458, (7242), 1171-5. Pubmed Link
"Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis", Oh, D.C.; Poulsen, M.; Currie, C.R.; Clardy, J. Nat Chem Biol. 2009, 5, (6), 391-3. Pubmed Link
"Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum", Patel, V.; Mazitschek, R.; Coleman, B.; Nguyen, C.; Urgaonkar, S.; Cortese, J.; Barker, R.H.; Greenberg, E.; Tang, W.; Bradner, J.E.; Schreiber, S.L.; Duraisingh, M.T.; Wirth, D.F.; Clardy, J. J Med Chem. 2009, 52, (8), 2185-7. Pubmed Link
"A colorimetric high-throughput screen for the detection of heme crystallization inhibitors", Rush, M.A.; Baniecki, M.L.; Mazitschek, R.; Cortese, J.F.; Wiegand, R.; Clardy, J.; Wirth, D.F. Antimicrob Agents Chemother. 2009, 53, (6), 2564-8. Pubmed Link
"Progestins activate the AKT pathway in leiomyoma cells and promote survival", Hoekstra, A.V.; Sefton, E.C.; Berry, E.; Lu, Z.; Hardt, J.; Marsh, E.; Yin, P.; Clardy, J.; Chakravarti, D.; Bulun, S.; Kim, J.J. J Clin Endocrinol Metab. 2009, 94, (5), 1768-74. Pubmed Link
"Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin", Wieland Brown, L.C.; Acker, M.G.; Clardy, J.; Walsh, C.T.; Fischbach, M.A. Proc Natl Acad Sci USA. 2009, 106, (8), 2549-53. Pubmed Link
"Biosynthesis of the Caenorhabditis elegans dauer pheromone", Butcher, R.A.; Ragains, J.R.; Li, W.; Ruvkun, G.; Clardy, J.; Mak, H.Y. Proc Natl Acad Sci USA. 2009, 106, (6), 1875-9. Pubmed Link
"Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.", Oh, D.C.; Scott, J.J.; Currie, C.R.; Clardy, J. Org Lett. 2009, 11, (3), 633-6. Pubmed Link
"Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors", Dong, C.K.; Patel, V.; Yang, J.C.; Dvorin, J.D.; Duraisingh, M.T.; Clardy, J.; Wirth, D.F. Bioorg Med Chem Lett. 2009, 19, (3), 972-5. Pubmed Link
"Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1", Berry, E.; Hardt, J.L.; Clardy, J.; Lurain, J.R.; Kim, J.J. Gynecol Oncol. 2009, 112, (2), 331-6. Pubmed Link
"Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum", Martyn, D.C.; Ramirez, A.P.; Beattie, M.J.; Cortese, J.F.; Patel, V.; Rush, M.A.; Woerpel, K.A.; Clardy, J. Bioorg Med Chem Lett. 2008, 18, (24), 6521-4. Pubmed Link
"Actin-aggregating cucurbitacins from Physocarpus capitatus", Maloney, K.N.; Fujita, M.; Eggert, U.S.; Schroeder, F.C.; Field, C.M.; Mitchison, T.J.; Clardy, J. J Nat Prod. 2008, Oct 30, epub ahead of print. Pubmed Link
"FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells", Fernandez de Mattos, S.; Villalonga, P.; Clardy, J.; Lam, E.W. Mol Cancer Ther. 2008, 7, (10), 3237-46. Pubmed Link
"Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase", Patel, V.; Booker, M.; Kramer, M.; Ross, L.; Celatka, C.A.; Kennedy, L.M.; Dvorin, J.D.; Duraisingh, M.T.; Sliz, P.; Wirth, D.F.; Clardy, J. J Biol Chem. 2008, 283, (50), 35078-85. Pubmed Link
"Bacterial protection of beetle-fungus mutualism", Scott, J.J.; Oh, D.C.; Yuceer, M.C.; Klepzig, K.D.; Clardy, J.; Currie, C.R. Science. 2008, 322, (5898), 63. Pubmed Link
"A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components", Butcher, R.A.; Ragains, J.R.; Kim, E.; Clardy, J. Proc Natl Acad Sci USA. 2008, 105, (38), 14288-92. Pubmed Link
"Codinaeopsin, an antimalarial fungal polyketide", Kontnik, R.; Clardy, J. Org Lett. 2008, 10, (18), 4149-51. Pubmed Link
"Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores", Kontnik, R.; Bosak, T.; Butcher, R.A.; Brocks, J.J.; Losick, R.; Clardy, J.; Pearson, A. Org Lett. 2008, 10, (16), 3551-4. Pubmed Link
"Citral sensing by TRANSient receptor potential channels in dorsal root ganglion neurons", Stotz, S.C.; Vriens, J.; Martyn, D.; Clardy, J.; Clapham, D.E. PLoS ONE. 2008, 3, (5), e2082. Pubmed Link
"Development of a fluorescence polarization based assay for histone deacetylase ligand discovery", Mazitschek, R.; Patel, V.; Wirth, D.F.; Clardy, J. Bioorg Med Chem Lett. 2008, 18, (9), 2809-12. Pubmed Link
"The evolution of gene collectives: How natural selection drives chemical innovation", Fischbach, M. A.; Walsh, C. T.; Clardy, J. Proc. Natl. Acad. Sci. USA. 2008, 105, (12), 4601-8. Pubmed Link
"Synthetic libraries of tyrosine-derived bacterial metabolites", Georgiades, S. N.; Clardy, J. Bioog Med Chem Lett. 2008, 18, (10), 3117-21. Pubmed Link
"Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition", Lautenschlager, C.; Leal, W. S.; Clardy, J. Structure. 2007, 15, (9), 1148-54. PubMed Link
"Detecting binding interactions using microarrays of natural product extracts", Schmitz, K.; Haggarty, S. J.; McPherson, O. M.; Clardy, J.; Koehler, A. N. J. Am. Chem. Soc. 2007, 129, (37), 11346-7. PubMed Link
"High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development", Junker, L. M.; Clardy, J. Antimicrob Agents Chemother. 2007, 51, (10), 3582-90. PubMed Link
"Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium", Clardy, J.; Brady, S. F. J. Bacteriol. 2007, 189, (17), 6487-9. PubMed Link
"One pathway, many products", Fischbach, M. A.; Clardy, J. Nat Chem Biol. 2007, 3, (7), 353-5. Pubmed Link
"Small-molecule pheromones that control dauer development in Caenorhabditis elegans", Butcher, R. A.; Fujita, M.; Schroeder, F. C.; Clardy, J. Nat Chem Biol. 2007, 3, (7), 420-22. Pubmed Link
"Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library", Schroeder, F. C.; Gibson, D. M.; Churchill, A. C.; Sojikul, P.; Wursthorn, E. J.; Krasnoff, S. B.; Clardy, J. Angew. Chem. Int. Ed. Engl. 2007, 46, (6), 901-4. PubMed Link
"High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity", Martyn, D. C.; Jones, D. C.; Fairlamb, A. H.; Clardy, J. Bioorg. Med. Chem. Lett. 2007, 17, (5), 1280-3. PubMed Link
"The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis", Butcher, R. A.; Schroeder, F. C.; Fischbach, M. A.; Straight, P. D.; Kolter, R.; Walsh, C. T.; Clardy, J. Proc. Natl. Acad. Sci. USA 2007, 104, (5), 1506-9. PubMed Link
"High-throughput Plasmodium falciparum growth assay for malaria drug discovery", Baniecki, M. L.; Wirth, D. F.; Clardy, J. Antimicrob. Agents Chemother. 2007, 51, (2), 716-23. PubMed Link
"FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding", Van Wagoner, R. M.; Clardy, J. Structure 2006, 14, (9), 1425-35. PubMed Link
"Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp.", Thammana, S.; Suzuki, H.; Lobkovsky, E.; Clardy, J.; Shimizu, Y. J. Nat. Prod. 2006, 69, (3), 365-8. PubMed Link
"Bisandrographolide from Andrographis paniculata activates TRPV4 channels", Smith, P. L.; Maloney, K. N.; Pothen, R. G.; Clardy, J.; Clapham, D. E. J. Biol. Chem. 2006, 281, (40), 29897-904. PubMed Link
"Differential Analysis of 2D NMR Spectra: New Natural Products from a Pilot-Scale Fungal Extract Library", Schroeder, F. C.; Gibson, D. M.; Churchill, A. C.; Sojikul, P.; Wursthorn, E. J.; Krasnoff, S. B.; Clardy, J. Angew. Chem. Int. Ed. Engl. 2006, 46, (6), 901-904. PubMed Link
"Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus", Maloney, K. N.; Hao, W.; Xu, J.; Gibbons, J.; Hucul, J.; Roll, D.; Brady, S. F.; Schroeder, F. C.; Clardy, J. Org. Lett. 2006, 8, (18), 4067-70. PubMed Link
"A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid", Jin, M.; Fischbach, M. A.; Clardy, J. J. Am. Chem. Soc. 2006, 128, (33), 10660-1. PubMed Link
"Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators", Hieronymus, H.; Lamb, J.; Ross, K. N.; Peng, X. P.; Clement, C.; Rodina, A.; Nieto, M.; Du, J.; Stegmaier, K.; Raj, S. M.; Maloney, K. N.; Clardy, J.; Hahn, W. C.; Chiosis, G.; Golub, T. R. Cancer Cell 2006, 10, (4), 321-30. PubMed Link
"Preparation of a psammaplysene-based library", Georgiades, S. N.; Clardy, J. Org. Lett. 2006, 8, (19), 4251-4. PubMed Link
"New antibiotics from bacterial natural products", Clardy, J.; Fischbach, M. A.; Walsh, C. T. Nat. Biotechnol. 2006, 24, (12), 1541-50. PubMed Link
"Stopping trouble before it starts", Clardy, J. ACS Chem. Biol. 2006, 1, (1), 17-9. PubMed Link
"A chemical study of cyclic depsipeptides produced by a sponge-derived fungus", Amagata, T.; Morinaka, B. I.; Amagata, A.; Tenney, K.; Valeriote, F. A.; Lobkovsky, E.; Clardy, J.; Crews, P. J. Nat. Prod. 2006, 69, (11), 1560-5. PubMed Link
"Human methionine aminopeptidase type 2 in complex with l- and d-methionine", Nonato, M.; Widom, J.; Clardy, J. Bioorg. Med. Chem. Lett. 2006, 16, 2580-2583. PubMed Link
"Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor," Hurt, D.; Widom, J.; Clardy, J. Acta Crystallogr. D. Biol. Crystallogr. 2006, 62, 312-323. PubMed Link
"Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase", Hurt, D.; Sutton, A.; Clardy, J. Bioorg. Med. Chem. Lett. 2006, 16, 1610-1615. PubMed Link
"Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps", Weibel, D. B.; Lee, A.; Mayer, M.; Brady, S. F.; Bruzewicz, D.; Yang, J.; Diluzio, W. R.; Clardy, J.; Whitesides, G. M. Langmuir 2005, 21, (14), 6436-42. PubMed Link
"Systematic Investigation of the Escherichia coli Metabolome for the Biosynthetic Origin of an Isocyanide Carbon Atom?, Brady, S.; Clardy, J. Angew. Chem. Int. Ed. Engl. 2005, 44, 7045-7048. PubMed Link
"Coil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein", Lautenschlager, C.; Leal, W.; Clardy, J. Biochem. Biophys. Res. Commun. 2005, 335, 1044-1050. PubMed Link
"Cloning and Heterologous Expression of Isocyanide Biosynthetic Genes from Environmental DNA", Brady, S.; Clardy, J. Angew. Chem. Int. Ed. Engl. 2005, 44, 7063-7065 PubMed Link
"Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export", Georgiades, S.; Clardy, J. Org. Lett. 2005, 7, 4091-4094. PubMed Link
"N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli", Brady, S.; Clardy, J. Org. Lett. 2005, 7, 3613-3616. PubMed Link
"The psammaplysenes, specific inhibitors of FOXO1a nuclear export", Schroeder, F.; Kau, T.; Silver, P.; Clardy, J. J. Nat. Prod. 2005, 68, 574-576. PubMed Link
"Using genomics to deliver natural products from symbiotic bacteria", Clardy, J. Genome Biol. 2005, 6, 232. PubMed Link
"Lessons from natural molecules", Clardy, J.; Walsh, C. Nature 2004, 432, 829-837. PubMed Link
"Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism", Stierle, D. B.; Stierle, A. A.; Hobbs, J. D.; Stokken, J.; Clardy, J. Org Lett 2004, 6, (6), 1049-52. PubMed Link
"A further study of the cytotoxic constituents of a milnamide-producing sponge", Sonnenschein, R. N.; Farias, J. J.; Tenney, K.; Mooberry, S. L.; Lobkovsky, E.; Clardy, J.; Crews, P. Org Lett 2004, 6, (5), 779-82. PubMed Link
"Long-chain N-acyltyrosine synthases from environmental DNA", Brady, S.; Chao, C.; Clardy, J. Appl. Environ. Microbiol. 2004, 70, 6865-6870. PubMed Link
"Palmitoylputrescine, an Antibiotic Isolated from the Heterologous Expression of DNA Extracted from Bromeliad Tank Water", Brady, S. F.; Clardy, J. J. Nat. Prod. 2004, 67, 1283-1286. PubMed Link
"Tyrosol is a quorum-sensing molecule in Candida albicans", Chen, H.; Fujita, M.; Feng, Q.; Clardy, J.; Fink, G.R. Proc. Natl. Acad. Sci. USA 2004, 101, 5048-5052. PubMed Link
"A chemical genetic screen identified inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells", Kau, T.R.; Schroeder, F.; Ramaswamy, S.; Wojciechowski, C.L.; Zhao, J.J.; Roberts, T.M.; Clardy, J.; Sellers, W.R.; Silver, P. Cancer Cell 2003, 4, 463-476. PubMed Link
"The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2", Calero, G.; Gupta, P.; Nonato, M.C.; Tandel, S.; Biehl, E.R.; Hofmann, S.L.; Clardy, J. J. Biol. Chem. 2003, 278, 37957-64. PubMed Link
"Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes", Jin, M.; Liu, L.; Wright, S.A.I.; Beer, S.V.; Clardy J. Angew. Chem. Int. Ed. 2003, 42, 2898-2901. PubMed Link
"The biosynthetic gene cluster of pantocin A provides insights into biosynthesis and a tool for screening", Jin, M.; Wright, S.A.I.; Beer, S.V.; Clardy J. Angew. Chem. Int. Ed. 2003, 42, 2902-2905. PubMed Link
"Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes", Sinars C. R.; Cheung-Flynn J.; Rimerman R. A.; Scammell J. G.; Smith D. F.; Clardy J. Proc. Natl. Acad. Sci. USA 2003, 100, 868-873. PubMed Link
"Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone", Brady, S. F.; Clardy J. Org. Lett. 2003, 5, 121-4. PubMed Link
"Structural basis of m7GpppG binding to the nuclear cap-binding protein complex", Calero, G.; Wilson, K. F.; Ly, T.; Rios-Steiner J. L.; Clardy, J. C.; Cerione, R. A. Nat. Struct. Biol. 2002, 9, 912-917. PubMed Link
"New natural product families from an environmental DNA (eDNA) gene cluster", Brady, S. F.; Chao, C. J.; Clardy, J. J. Am. Chem. Soc. 2002, 124, 9968-9969. PubMed Link
"Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha", Nonato, M. C.; Widom, J.; Clardy J. J. Biol. Chem. 2002, 277, 17057-17061. PubMed Link
"Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity", Liu, S.; Cerione, R. A.; Clardy, J. Proc. Natl. Acad. Sci USA 2002, 99, 2743-2747. PubMed Link
"Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracillis", Wagenaar, M. M.; Gibson, D. M.; Clardy, J. Org. Lett. 2002, 4, 671-673. PubMed Link
"Synthesis and biological evaluation of analogues of the antibiotic pantocin B", Sutton, A. E.; Clardy, J. J. Am. Chem. Soc. 2001, 123, 9935-9446. PubMed Link
"The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus", Brady, S. F.; Bondi, S. M.; Clardy, J. J. Am. Chem. Soc. 2001, 123, 9900-9901. PubMed Link
"Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA", Brady, S. F.; Chao, C. J.; Handelsman, J.; Clardy, J. Org. Lett. 2001, 3, 1981-1984. PubMed Link
"Dicerandrols, new antibiotic and cytotoxic dimers producted by the fungus Phomopsis logicolla isolated from an endangered mint", Wagenaar, M. M.; Clardy, J. J. Nat. Prod. 2001, 64, 1006-1009. PubMed Link
"Two new roridins isolated from Myrothecium sp.", Wagenaar, M. M.; Clardy, J. J. Antibiotics 2001, 6, 517-520. PubMed Link
"The synthesis of potentially selective inhibitors of dihydroorotate dehydrogenase. The utilization of chemoselective Suzuki cross-coupling reactions in parallel synthesis", Sutton, A. E.; Clardy, J. Tetrahedron Lett. 2001, 42, 547-552.
"Long-chain N-Acyl amino acid antibiotics isolated from heterologously expressed environmental DNA", Brady, S. F.; Clardy, J. J. Am. Chem. Soc. 2000, 122, 12903-12904.
"CR377, a new pentaketide antifungal agent isolated from an endophytic fungus", Brady, S. F.; Clardy, J. J. Nat. Prod. 2000, 63, 1447-1448. PubMed Link
"The cytosporones, new octaketide antibiotics isolated from an endophytic fungus", Brady, S. F.; Wagenaar, M. M.; Singh, M. P.; Janso, J. E.; Clardy, J. Org. Lett. 2000, 2, 4043-4046. PubMed Link
"Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus", Brady, S. F.; Singh, M. P.; Janso, J. E.; Clardy, J. Org. Lett. 2000, 2, 4047-4049. PubMed Link
"Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride", Das, A. K.; Bellizzi, J. J.; Tandel, S.; Biehl, E.; Clardy, J.; Hofmann, S. L. J. Biol. Chem. 2000, 275, 23487-23851. PubMed Link
"Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115", Singh, M. P.; Janso, J. E.; Luckman, S. W.; Brady, S. F.; Clardy, J.; Greenstein, M.; Maiese, W. M. J. Antibiotics 2000, 53, 256-261. PubMed Link
"The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis", Bellizzi, J. J. III; Widom, J.; Kemp, C.; Lu, J. Y.; Das, A. K.; Hofmann, S. L.; Clardy, J. Proc. Nat. Acad. Sci. 2000, 97, 4573-4578. PubMed Link
"Guanacastepene, a fungal-derived diterpene antibiotic with a new carbon skeleton", Brady, S. F.; Singh, M.; Janso, J.; Clardy, J. J. Am. Chem. Soc. 2000, 122, 2116-2117.
"Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex", Sandler, B. H.; Nikonova, L.; Leal, W. S.; Clardy, J. Chem. Biol. 2000, 7, 143-151. PubMed Link
"Structure of human dihydroorotate dehydrogenase in complex with antiproliferative agents", Liu, S.; Neidhardt, E. A.; Grossman, T. H.; Ocain, T.; Clardy, J. Structure 2000, 8, 25-35. PubMed Link
"The total synthesis of Pantocin B", Sutton, A. E.; Clardy, J. Org. Lett. 2000, 2, 319-321. PubMed Link
"Pantocin B, an antibiotic from Erwinia herbicola discovered by heterologous expression of cloned genes", Brady, S. F.; Wright, S. A.; Lee, J. C.; Sutton, A. E.; Zumoff, C. H.; Wodzinski, R. S.; Beer, S. V.; & Clardy, J. J. Am. Chem. Soc. 1999, 121, 11912-11913.